Colorectal Cancer The Third Most Common Cancer - 901 Words

Colorectal cancer (CRC) is the third most common cancer in the world, with nearly 1.4 million new cases diagnosed in 2012. Almost 55% of the cases occur in more developed regions. About 95% of those diagnosed are adenocarcinomas, malignant tumors that form from glandular structures of the epithelial tissues, and mortality is primarily due to hepatic metastasis. It is predicted that by 2035, there will be 2.4 million cases of colorectal cancer diagnosed annually worldwide. http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics No major breakthroughs have been made in the treatment of metastatic CRC , many new therapies failing to improve 5-year survival rates. Conventional chemotherapy efficiently targets tumor bulk, however, a small subpopulation of cells, known as cancer stem cells (CSCs), contribute to resistance to therapy, tumor regrowth and relapse. These CSCs have been shown to be responsible for the initiation and maintenance of tumors, as well as chemotherapeutic resistance and cancer recurrence. Accordingly, targeting this group of cells has become a major key to improve the treatment of CRC. Salinomycin is a polyether antibiotic used in chicken fodder as an antiprotozoal agent that acts upon Coccidia parasites. Salinomycin induces cell death in various solid tumors, such as prostate cancer, via downregulation of Skp2, accumulation of reactive oxygen species and mitochondrial membrane depolarization. Salinomycin has alsoShow MoreRelatedColorectal Cancer : The Third Most Common Type Of Cancer1296 Words   |  6 PagesIntroduction Colorectal cancer (CRC) is ranked as the third most common type of cancer in women. Furthermore, it is the fourth most dominant kind of cancer in men recorded all over the world. Consequently, CRC accounts for over a million new cases and more than half a million deaths every year. Colonoscopy allows early discovery and removal of precancerous lesions and may, therefore, effectively prevent or reduce the risk of Colorectal cancer. Although studies under hugely standardized conditionsRead MoreColorectal Cancer : The Third Most Common Cancer Among Men And Women Essay1330 Words   |  6 PagesColorectal cancer is the third most common cancer among men and women in the United States, and mutations in the MUTYH gene significantly increase the risk of developing polyps that may evolve into cancer.1,2 Biallelic mutations in the MUTYH gene can lead to MYH-Associated Polyposis (MAP), which causes the growth of dozens to hundreds of polyps, furthering increasing the risk for colon cancer.2 Meanwhile, recent studies have shown that both biallelic and monoallelic mutations can contribute toRead MoreColorectal Cancer And Its Effects On The Digestive System853 Words   |  4 PagesColorectal Cancer Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectum cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus. Digestive system in our body Colon and rectum are both located in the digestive system. There are two partsRead MoreColorectal Cancer : Cancer And Cancer1140 Words   |  5 PagesColorectal cancer, also called colon cancer, is a disease in which cancer cells form in the colon, which is the upper five to six feet of the large bowel, or large intestine. Hereditary factors play a role in colorectal cancer risk, but it can also be caused by outside factors. â€Å"Excluding skin cancer, it is the third most common cancer diagnosed in both men and women in the United States† (American Cancer Society). Colorectal cancer has been known since ancient times, and it is becoming less fatalRead MoreThe Association Between Low Hdl Blood Levels And Colonic Cancer1648 Words   |  7 Pagessyndrome have an increased risk of colorectal cancer (CRC). One of the possible mechanisms is that lipids and lipoproteins have been found to be associated with neoplastic processes as well as inflammation, insulin resistance and oxi dative stress. On the other side, some of the factors that influence lipid and lipoprotein concentration unfavorably (ie. smoking, obesity, a high fat and low fiber diet consumption) can contribute to the development of colon cancer as well. The purpose of this studyRead MoreColorectal Cancer : Disease Risk Factor Research Paper Essay1321 Words   |  6 PagesDarko Colorectal Cancer Disease Risk Factor Research Paper HLTH 435 Chronic diseases are becoming increasingly prevalent in the United States and around the world. Although preventable, chronic diseases can last anywhere from 3 months to a life time. Cancer is a chronic disease that is termed epidemic because the number of cases has increased highly over the years. Colorectal cancer, also known as colon cancer is one of the many cancers and it accounts for over 9% of all cancer incidentsRead MoreFatty Acid Composition Of Adipose Tissue And Colorectal Cancer : A Case Control Study845 Words   |  4 Pagescomposition of adipose tissue and colorectal cancer: a case-control study Colorectal cancer is considered as the third most common cancers worldwide that usually leads to the death of the patient. Studies have proved that lifestyle factors great influence the development and spread of cancer. Modifying the lifestyle can reduce the risk of getting colorectal cancer by 70%. It is noted that more consumption of red and processed meat increase the risk of developing colorectal cancer. However, high intake ofRead MoreTesting Based Fecal Occult Blood Test Sensitivity And Specificity1358 Words   |  6 PagesGuaiac-based Fecal Occult Blood Test Sensitivity and Specificity Colon cancer The large intestines are a part of the digestive system (Colorectal cancer, 2015). The large intestines (large bowels) are made up of the colon and the rectum (What is colorectal cancer, 2016). The colon is five feet long muscular tube that makes up the majority of the large bowel (What is colorectal cancer, 2016). After food goes through the small intestines, of the digestive system, the colon absorbs the salt and waterRead MoreDevelopment Of Drugs With High Potency And Inhibitory Activity1618 Words   |  7 Pagesmade testing specific sensitizing mutation necessary. (1) (EGFR) T790M mutation a successful example of a biomarker for non-small cell lung cancer (NSCLC) treatment with Osimertinib that gained a wide acceptance in clinical practice in Europe and US (), One question that needs to be asked, however, is whether testing for similar mutations in different cancer will be of clinical value. an unknown subpopulation of patients with CRC will have an activating EGFR mutation, su ch as L858R, which is thoughtRead MoreCancer : Etiology, Symptoms, Diagnosis, And Treatment1718 Words   |  7 Pages Colon Cancer: Etiology, Symptoms, Diagnosis, and Treatment Harold Scott Delaware Technical Community College Biology Professor Riggio November 18, 2014 Abstract A well-known fact is that cancer plays a major role in the area of health science in the United States. Cancer touches many individuals and many families across the nation. With a variety of types of cancer as well as causes, symptoms, and treatments cancer is a very broad topic of research. In particular my research focuses on